Modafinil: a double-blind multicentric
study.
Billiard M, Besset A, Montplaisir J,
Laffont F, Goldenberg F, Weill JS, Lubin S.
Service de Neurologie B,
Hopital Gui de Chauliac, Montpellier, France
Sleep 1994 Dec;17(8 Suppl):S107-12
ABSTRACT
Modafinil is a central putative
alpha-1 postsynaptic agonist with vigilance-promoting properties. Fifty
narcoleptics (33 male and 17 female) participated in a multicentric study
aimed at assessing the effects of the compound on night sleep, feeling on
awakening, excessive daytime sleepiness and cataplexy. Modafinil
was
administered in a double-blind cross-over design at a daily dosage of 300 mg
versus placebo. The duration of the study was 12 weeks, including a 2-week
"run in" period with placebo, a first 4-week treatment period with
either modafinil or placebo, a 2-week wash-out period with placebo and a
second 4-week treatment period with either placebo or modafinil. Daily
evaluation was based on a sleep log, visual analog scales, a sleep
questionnaire and a clinical global index. Sleep laboratory evaluation took
place on nights 1, 28, 42 and 70. It included 1 night of polysomnography
preceded by a questionnaire on therapeutic and side effects, and a maintenance
of wakefulness test (MWT). Sleep logs did not show any modification of night
sleep, but a reduction of daytime sleepiness and sleep. Feeling on awakening
was not modified. An overall benefit was noted by physicians as well as by
patients. MWT disclosed a positive effect of modafinil
on excessive daytime
sleepiness. Cataplexy was not modified.
1. modafinil is
a potential treatment for
fibromyalgia
2. modafinil improves
fatigue in patients with multiple sclerosis
3. modafinil offers
promise as an augmentation to antidepressants
4. modafinil excessive sleepiness in
Parkinson's disease
5. modafinil excessive
daytime sleepiness in Parkinson's disease
6. modafinil may
be useful for attention-deficit/hyperactivity disorder
7. modafinil benefits
cerebral palsy in an unknown way
8. modafinil
article
9. modafinil
amplification of cortical serotonin release
10. modafinil
treatment of alcoholic organic brain syndrome
11. modafinil
effect on melatonin, cortisol, and growth hormone
12. modafinil
in obstructive sleep apnea-hypopnea syndrome
13. modafinil
vs dextroamphetamine in treatment of adult ADHD
14. modafinil
efficacy in narcolepsy
15. modafinil
switching from narcolepsy drugs to modafinil
16. modafinil
drug of choice for narcolepsy
17. modafinil
dopaminergic transmission mediates CNS stimulants
18. modafinil
for daytime sleepiness in sleep apnea
19. modafinil
treatment of residual excessive daytime sleepiness
20. modafinil
in the treatment of
narcolepsy
21. modafinil
and naps as counter measures in sleep deprivation
22. modafinil
effect on narcolepsy
23. modafinil
as a treatment for excessive daytime sleepiness
24. modafinil
a narcolepsy study
25. modafinil
use in a sleep deprivation experiment
26. modafinil for
sustaining the alertness of helicopter pilots
27. modafinil the
unique properties of a new stimulant
28. modafinil dosage
and safety
29. modafinil in treatment of fatigue in
multiple sclerosis
30. modafinil non-addictive potential of modafinil
31. modafinil successful
treatment of hypersomnia & narcolepsy
32. modafinil physiological effects of modafinil in drug abusers
33. modafinil narcolepsy:
symptoms and management
34. modafinil cognitive enhancing effects of modafinil
